The list of individual drugs that cause kidney damage is so long that it’s hard to decide on the top ten. So I’ve chosen to list them by type of drug: antibiotic, analgesic, etc.
Top ten drugs that cause kidney damage:
1. Antibiotics, including ciprofloxacin, methicillin, vancomycin, sulfonamides.
2. Analgesics, including acetaminophen and non-steroidal anti-inflammatory drugs (NSAID): aspirin, ibuprofen, naproxen, and others available only by prescription.
3. COX-2 inhibitors, including celecoxib (brand name Celebrex). Two drugs in this class have been withdrawn from the market because of cardiovascular toxicity: rofecoxib (brand name Vioxx), and valdecoxib (brand name Bextra). These drugs are a special class of NSAID that was developed to be safer for the stomach but have the same risk as other NSAIDs for kidney damage.
4. Heartburn drugs of the proton pump inhibitor class, including omeprazole (brand name Prilosec), lansoprazole (brand name Prevacid), pantoprazole (brand name Protonix), rabeprazole (brand names Rabecid, Aciphex), esomeprazole (brand names Nexium, Esotrex). See Ref. 4.
5. Antiviral drugs, including acyclovir (brand name Zovirax), used to treat herpes infection, and indinavir and tenofovir, both used to treat HIV.
6. High blood pressure drugs, including captopril (brand name Capoten).
7. Rheumatoid arthritis drugs, including infliximab (brand name Remicade); chloroquine and hydroxychloroquine, which are used to treat malaria and systemic lupus erythematosus as well as rheumatoid arthritis.
8. Lithium used to treat bipolar disorder.
9. Anticonvulsants, including phenytoin (brand name Dilantin) and trimethadione (brand name Tridione), used to treat seizures and other conditions.
10. Chemotherapy drugs, including interferons, pamidronate, cisplatin, carboplatin, cyclosporine, tacrolimus, quinine, mitomycin C, bevacizumab; and anti-thyroid drugs, including propylthiouracil, used to treat overactive thyroid.
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